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Project Overview
Storyboard

Can normal cellular processes be used to fight neurodegenerative diseases?

For healthy cells, a small amount of protein misfolding and aggregation happens all the time.

These errant proteins are cleared from the cell through a normal cellular process called autophagy.

Patients with neurodegenerative diseases like Parkinson's, Huntington's, and Alzheimer's

show a build up of specific misfolded proteins

that have a tendency to aggregate

and can accumulate to cytotoxic levels.

Indeed, in some of these patients, the process of autophagy is impaired.

At Neuropore Therapies NPT520-34, one way we target diseases stemming from protein misfolding and aggregation

is by identifying novel small molecule compounds that enhance autophagy.

By designing compounds that promote clearance of a specific misfolded protein, we hope to stop disease by preventing its underlying cause—the accumulation of toxic protein aggregates.

Neuropore Therapies NPT520-34, our most advanced autophagy-promoting compound, is ready for development, and more are in the pipeline.

Realize dreams through innovation. Overcome treatment limitations with us. Come explore solutions with us as a partner.